Management of moderate to severe chronic low back pain with buprenorphine buccal film using novel bioerodible mucoadhesive technology
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چکیده
منابع مشابه
Management of moderate to severe chronic low back pain with buprenorphine buccal film using novel bioerodible mucoadhesive technology
With a global prevalence of ~9%-12%, low back pain (LBP) is a serious public health issue, associated with high costs for treatment and lost productivity. Chronic LBP (cLBP) involves central sensitization, a neuropathic pain component, and may induce maladaptive coping strategies and depression. Treating cLBP is challenging, and current treatment options are not fully satisfactory. A new BioEro...
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A buccal film of buprenorphine (BBUP) was evaluated for safety and efficacy in a multicenter, double-blind, placebo-controlled, enriched-enrollment, randomized-withdrawal study in opioid-experienced patients (30 to ≤160 mg/d morphine sulfate equivalent) with moderate to severe chronic low back pain taking around-the-clock opioid analgesics. Patients' opioid doses were tapered to ≤30 mg morphine...
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BACKGROUND This open-label, single-arm study was conducted to evaluate the long-term safety and efficacy of a novel buprenorphine formulation, buprenorphine buccal film, in the treatment of moderate-to-severe chronic pain requiring around-the-clock opioids. METHODS The primary purpose of this study was to evaluate the long-term safety and tolerability of buprenorphine buccal film. Five hundre...
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متن کاملA comparative study of trunk proprioception between patients with chronic non-specific low back pain and discopathic low back pain
Introduction: Low back pain is one of the most common disorders in modern society. Disturbed properioception can be a possible cause of low back pain and can cause recurrence of low back pain. Previous studies have shown that low back pain reduces proprioception due to instability in the low back. Since the degenerative process of disc herniation is one of the important factors in exacerbating ...
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ژورنال
عنوان ژورنال: Journal of Pain Research
سال: 2016
ISSN: 1178-7090
DOI: 10.2147/jpr.s87952